gene fusion การใช้

• ERG and ETV1 are known gene fusions found in prostate cancer.
• Most cases are characterised by GRM1 gene fusion or promoter swapping.
• They share a derived triple-gene fusion, absent from bikonts.
• At present, scientists have identified 358 gene fusions involving 337 different genes.
• This database is called Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer
• Gene fusion research later revealed that the clade Amoebozoa, was ancestrally uniciliate.
• Gene fusions involving NTRK1 have been shown to be oncogenic, leading to the constitutive TrkA activation.
• Many whole gene fusions are fully functional, and can still act to replace the original peptides.
• Multiple Ets factors have been found to be associated with cancer, such as through gene fusion.
• The gene fusion produces a chimeric protein segment from which a new antigenic peptide can be derived.
• This approach led to the identification of eleven novel gene fusion transcripts originated from previously unknown chromosomal rearrangements.
• An interesting example is gene fusions resulting from specific chromosomal translocations frequently encountered in certain types of cancer.
• Clinical data supports the use of crizotinib in lung cancer patients with " ROS1 " gene fusions.
• Translocation results in an oncogenic BCR-ABL gene fusion that can be found on the shorter derivative 22 chromosome.
• JAK2 gene fusions with the TEL ( ETV6 ) ( TEL-JAK2 ) and PCM1 genes have been found in leukemia patients.
• Progress in the identification of new, previously uncharacterized genes is being made using nonbiased screening strategies that rely on gene fusion technologies.
• The ETV6-NTRK3 gene fusion was originally identified in congenital fibrosarcoma and its correlate in the salivary gland, mammary analogue secretory carcinoma.
• Since chromosomal translocations play such a significant role in neoplasia, a specialized database of chromosomal aberrations and gene fusions in cancer has been created.
• Other techniques like reverse-transcriptase PCR ( RT-PCR ) can also be used to detect lung cancers with an ALK gene fusion but not recommended.
• Current DBPs include gene fusion in cancers, major organ-specific complications of diabetes, nutrition and obesity, and co-morbid disease associations of bipolar disorder.